World News – CA – Eight out of 10 patients at Covid-19 hospital are vitamin D deficient, study

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Posted: 15:22 GMT, October 27, 2020 | Updated: 3:42 p.m. GMT, October 27, 2020

Further evidence that vitamin D could protect people against coronavirus emerged today after a study found nutrient deficiencies from the sun are four times more common in hospital patients

A mountain of research from around the world has painted a clear picture: infected patients who do not have enough vitamin D are more likely to end up in hospital

But so far scientists have been unable to determine whether nutrient deficiency makes people more vulnerable to disease or whether discomfort causes vitamin D levels to drop

Spanish experts have now discovered more evidence to suggest that inexpensive vitamin D supplements – which cost as little as 6 pence per pill – may prove beneficial

Experts from the University of Cantabria in Santander examined 216 patients with Covid-19 at Valdecilla hospital in the city of northern Spain

Eighty-two percent were vitamin D deficient, while only 18 percent had adequate levels of nutrients – a fourfold difference

This was compared to the 47 percent of deficient people in a control group who did not have the infection

Forty-four of the patients deficient in Covid-19 were transferred to intensive care because their illness worsened and 37 needed mechanical ventilation – but their vitamin D levels were not lower than those the rest of the group The other patients recovered without the need for additional care

Spanish researchers are now calling for coronavirus patients to be treated with vitamin D supplements «  because this approach could have beneficial effects  » and there are few negative side effects

While research does not prove that a deficiency caused them to fall ill enough to require hospital care, this is the latest in a series of studies to show similar results

Others have suggested that treating Covid-19 hospital patients with cheap vitamin D supplements increases their chances of survival and speeds recovery But the lack of clinical trials, the gold standard of scientific research, has kept scientists from saying for sure they work.

Overwhelming evidence pointing to the benefits of vitamin D prompted UK researchers to sit down and take note earlier this month A trial was launched by Queen Mary’s University in London, which will see 5,000 volunteers take the vitamin for six months to see if it can keep people from getting or getting very sick with the disease

The study at the University of Cantabria in Santander looked at 216 patients with Covid-19 (in black) and compared their vitamin D levels to a control group (in gray) A level of 20 nanograms / milliliter at 50 ng / mL is considered a healthy concentration of vitamin D Anything below 13 ng / mL signals a deficiency

Other studies have suggested that treating Covid-19 hospital patients with cheap vitamin D supplements – costing only 6 pence a pill – increases their chances of survival and speeds up their recovery

Dr Jose Hernandez, University of Santander, said: «  One approach is to identify and treat vitamin D deficiencies, especially in high risk people such as the elderly, patients with co-morbidities and residents of nursing homes, who are the main target population for Covid-19

Vitamin D treatment should be recommended in Covid-19 patients with low levels of vitamin D circulating in the blood, as this approach may have beneficial effects on the musculoskeletal and immune system ‘

His study retrospectively examined 216 patients with Covid-19 hospitalized with the disease in March, when Spain was the epicenter of the virus in Europe

They scanned hospital records to analyze their vitamin D levels on admission and compared them to a randomly selected control group from the population

Of the 216 hospital patients, vitamin D deficiency was found in 822% of cases – compared to 472 percent of healthy people

Experts consider that a level of 25 nanograms / milliliter of vitamin D or more is healthy Below 25 ng / ml is considered a weak signal deficit and less than 20 ng / ml

In addition to supplements, vitamin D is also available in foods, including fatty fish, red meat and eggs (right) A Singaporean study conducted earlier this year among nearly 800 people revealed that nearly 99% of deceased Covid-19 patients had vitamin D deficiency (left)

A correlation graph showing the relationship between vitamin D levels (bottom, measured in nmol / L) versus coronavirus infection numbers by the University of East Anglia Countries with low vitamin levels D tend to have the highest case rates per million – but the graph is from a study in May, when outbreaks were vastly different from what they do now and testing was spotty in most countries

A study by the University of Tehran, Iran, and Boston University analyzed data from 235 hospital patients with Covid-19 Patients who had enough vitamin D – at least 30 ng / mL – were 515% less likely to die from the disease Although no one in the study under 40 died, deaths (in red) were more common in people with vitamin D deficiency (below the black line ) of all ages

University of Chicago researchers studying vitamin D levels of 500 Americans have found 60% higher rates of Covid-19 in people with low levels of the ‘sunshine vitamin’

Doctors will finally test whether vitamin D can actually protect people against Covid-19 amid growing evidence that the 3p supplement per day could save life

Researchers at Queen Mary University in London will recruit 5,000 volunteers to take the vitamin for six months if they are not already taking large doses

Experts will then assess whether participants are less likely to catch the virus and develop a severe episode of the disease during the winter months.

A mountain of studies has revealed that an overwhelming amount of people who test positive for Covid-19 do not have enough vitamin D in their bodies, and the sickest patients are often deficient

Britons are most at risk for vitamin D deficiency between October and April, when sunlight levels are too low for the body to produce the vitamin – darker skinned people run an even higher risk

About two in five Britons are deficient in winter, when respiratory infections are most common In the United States, at least two in five citizens also lack adequate levels of the vitamin

This has led doctors to demand inexpensive vitamin D supplements – which cost as little as 3 pence a day and have no dangerous side effects – to fight the disease, rather than wait for a vaccine that might never be found

Although heads of health advise residents to receive supplements year-round as they rarely go out, academics have found this does not happen in nursing homes in the south-east of England

Trial volunteers will be given tablets containing 800 IU or 3200 IU per day of the vitamin, which they will be asked to take for six months

There will also be a control group taking the NHS recommended amount of 400 IU per day

Researchers will follow the incidence of acute respiratory infections diagnosed by the doctor or confirmed in the laboratory in participants during the trial, to see if the supplements affected their risk or the severity of the infection.

Volunteers will also need to take a finger prick test to check their vitamin D levels

Dr David Jolliffe, of Queen Mary University in London, said the study had the potential to give a ‘definitive answer’ on whether vitamin D could protect against coronavirus

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“Vitamin D supplements are inexpensive, low risk, and widely available; if they prove to be effective, they could contribute significantly to our global fight against the virus,  » he said

Researchers found that those with lower amounts of the « sunshine vitamin » had a higher prevalence of high blood pressure and heart disease

The study suggests an occasional link between a lack of vitamin D – produced by the body when exposed to the sun – and moderate to severe illness from the virus

But scientists have yet to be able to determine whether a vitamin D deficiency makes people more vulnerable to Covid-19 or whether the disease causes vitamin D levels to drop after infection, which is the cases with other infections

People with darker skin are at a greater risk of vitamin D deficiency because the body has a harder time absorbing and converting sunlight

Most of the patients in the study group also had underlying health conditions or were overweight – factors that weaken the immune system and make it harder for the body to produce vitamin D

It comes after researchers at Queen Mary University in London launched a trial exploring the nutrient’s potential benefits on Covid-19

Scientists will give 5,000 volunteers the vitamin for six months if they are not already taking large doses

Experts will then assess whether participants are less likely to catch the virus and develop a severe episode of the disease during the winter months.

Britons are most at risk for vitamin D deficiency between October and April, when sunlight levels are too low for the body to produce the vitamin – darker skinned people run an even higher risk

About two in five Britons are deficient in winter, when respiratory infections are most common In the United States, at least two in five citizens also lack adequate levels of the vitamin

This has led doctors to ask for cheap vitamin D supplements – which have no dangerous side effects – to fight the disease, rather than waiting for a vaccine that might never be found

Arguments about the link between vitamin D deficiency and its observed link with poor Covid-19 results started to gain momentum in May

The problem is that there is a lack of benchmark medical research – randomized controlled trials that compare people who get the supplement with those who don’t have to see which group is doing better

Only one study has done so so far, conducted by the University of Cordoba in Spain and published last month

Researchers have given large doses of calcifediol – a type of vitamin D supplement – to 50 patients hospitalized with the disease

There were no deaths among the volunteers receiving the vitamin and all 50 patients were eventually released at the end of the study But two of the 26 patients in a control group, who did not receive the tablets, died

Only one patient who received calcifediol felt sick enough to be admitted to intensive care, while half of the participants in the control group were taken to intensive care and two died

But many scientists criticized the study, saying its sample size was too small for firm conclusions to be drawn on the impact of vitamin D

Nonetheless, this was the most promising result for vitamin trials so far, and matches previous research that correcting a vitamin deficiency could halve death rates.

A Northwestern University study, published in May, found that patients with Covid-19 with severe vitamin D deficiency are twice as likely to experience major complications and die

Almost 99% of Covid-19 patients who are vitamin D deficient die, according to a study by Indonesian researchers who analyzed hospital records of 780 people who tested positive for SARS-CoV-2

Results revealed 989% of infected patients defined as vitamin D deficient – less than 20 ng / ml – died Yet this fell to only 41 percent for patients who had had enough of the nutrient

Researchers warned the study was not definitive, as patients with high vitamin D levels were healthier and younger

Another study by the University of Tehran, Iran, and Boston University, found that patients at Covid-19 hospital who had enough vitamin D – at least 30 ng / mL – were 515% less likely to die from the disease

The study of 235 hospitalized patients with Covid-19 also showed that those with enough vitamin D had a significantly lower risk of becoming seriously ill or needing ventilation

Patients who had lots of nutrients also had less inflammation – often a deadly side effect of Covid-19

However, these studies had shortcomings, such as a lack of recognition of confounding factors, such as smoking, and socioeconomic status, which were not recorded for all patients but could have an impact. impact on disease severity

There have also been at least three studies that have suggested that those with enough vitamin D are less likely to catch the coronavirus in the first place

What have the scientists studied? 50 Covid-19 hospital patients with Covid-19 received vitamin D Their health results were compared to 26 volunteers in a control group who did not receive the tablets

What did they find? Only one of the 50 patients required intensive care and none died Half of the 26 people with the virus who did not take vitamin D were subsequently admitted to intensive care and two died

What were the limitations of the study? Small pool of volunteers Patients’ vitamin D levels were not checked prior to admission Co-morbidities were not taken into consideration

What have the scientists studied? 500 Americans ‘vitamin D levels were tested The researchers then compared the volunteers’ levels with the number of coronaviruses caught

What did they find? 60% higher Covid-19 rate in people with low levels of the «  sunshine vitamin  »

The researchers did not check for other compositional factors It is not known whether the volunteers were deficient in vitamin D at the time of their coronavirus tests. People’s age, occupation and place of residence – factors which significantly increase the risk of contracting the virus – have not been taken into account

What did they find? Patients who had enough vitamin D – at least 30 ng / mL – were 515% less likely to die from the disease They also had a significantly lower risk of becoming seriously ill or needing ventilation Patients who had plenty of nutrients also had less inflammation – often a deadly side effect of Covid-19

What were the limitations of the study? Confounding factors, such as smoking, and socioeconomic status were not recorded for all patients and could have an impact on the severity of the disease

What have the scientists studied? 782 people who tested positive for the coronavirus had their pre-infection vitamin D levels evaluated retrospectively and compared to healthy people

What did they find? People with vitamin D levels below 30 ng / ml – optimal – were 45% more likely to test positive and 95% more likely to be hospitalized

What were the limitations of the study? Did not examine underlying health issues and check vitamin D levels at the time of infection

What have the scientists studied? Comparison of vitamin D levels in nearly 200 patients at Covid-19 hospital with a control group of more than 2,000 healthy people

What did they find? Men hospitalized with the infection were significantly more likely to have vitamin D deficiency than healthy men of the same age Deficiency rates were 67% in the COVID-19 patient group and 49% in the control group The same was not found for women

What were the limitations of the study? Independent Scientists Claim Vitamin D Blood Levels Decrease When People Develop Serious Disease, Which Study Did Not Take Into Account That Suggests It Is The Disease That Causes Vitamin D Blood Levels To Drop in this study, and not the other way around

What have the scientists studied? 50 hospitalized patients with Covid-19 were checked for levels of all vital vitamins and compared to a control group

What did they find? 76% of them had vitamin D deficiency, and severe vitamin D deficiency (<10 ng / dl) was observed in 24% of patients with Covid-19 and only 7% in the control group

What did they find? Almost 99% of deceased patients had vitamin D deficiency Among patients with vitamin D levels above 30 ng / ml – considered optimal – only a percentage died

What were the limitations of the study? It has not been evaluated by scientific colleagues, a process that often reveals flaws in studies

What have the scientists studied? Vitamin D levels in 449 people from the British Biobank who had confirmed Covid-19 infection

What did they find? Vitamin D deficiency was associated with an increased risk of infection – but not after adjusting for founders such as ethnicity This led the team to conclude that their «  results do not support a potential link between concentrations vitamin D and the risk of infection with Covid-19′

What have the scientists studied? Average vitamin D levels in populations in 20 European countries were compared to Covid-19 infection and death rates at the time

What did they find? The average level of vitamin D in each country was’ strongly associated ‘with higher levels of Covid-19 cases and deaths The authors said at the time:’ The population group most vulnerable to Covid -19 is also the one with the most vitamin D deficiency

What were the limitations of the study? The number of cases in each country was affected by the number of tests performed, as well as the different measures each country took to prevent the spread of the infection. And it only looked at correlation, not causation

What have the scientists studied? Cross-data from dozens of studies around the world that included vitamin D levels in Covid-19 patients

What did they find? Patients with severe deficiency are twice as likely to experience major complications and die

What were the limitations of the study? Cases and deaths in each country have been affected by the number of tests performed

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Vitamin, coronavirus, vitamin D deficiency

News from the world – CA – Eight out of 10 patients at Covid-19 hospital are vitamin D deficient, study


SOURCE: https://www.w24news.com

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